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The Journal Nature has partnered with Thomson Reuters Web of Science database to determine the top 100 most cited papers.

Looking at 100 years of data, and the 58 million items stored in the Web of Science database, 3 articles have been cited more than a 100 000 times, all published prior to 1980, all in the biology field.

Google Scholar came up with an alternative ranking, click to see the comparison for 10 papers.